Neurotalk S5E10: Bernardo Sabatini

Today, our guest is Professor Bernardo Sabatini, the Alice and Rodman W. Moorhead III Professor of Neurobiology at Harvard University. In this episode, we will talk about overcoming technological barriers, scientific bloodlines, and when the music industry meets science.

(P.S. The music video to which Prof. Sabatini refers: http://mssngpeces.com/projects/interactive/chairlift-met-before/)

All different and yet the same: searching for biological similarities between individuals with autism

“If you know one child with autism,” the saying goes, “you know one child with autism.” Though an estimated 1 in 68 children in the United States will be diagnosed with Autism Spectrum Disorder (ASD), their diverse personalities seem to defy categorization. Yet, dating back to the first report on ASD by Austrian-American psychiatrist Leo Kanner, clinicians have identified clear themes in the children’s behavior. Researchers have long struggled to pinpoint the common biological pathway underlying these behavioral commonalities seen in ASD. A study published last year by Silvia De Rubeis and her colleagues took advantage of rare risk variants to find molecular commonalities that underlie the behavioral traits that link autism spectrum disorders together. 

Read More

No accounting for taste? Giant sloths, ancient pumpkins, and evolutionary genetics in bitter taste receptors.

No accounting for taste? Giant sloths, ancient pumpkins, and evolutionary genetics in bitter taste receptors.

Though domesticated pumpkins and other gourds (think zucchinis, acorn squashes, butternut squashes), are edible (and tasty!), their wild cousins produce a toxic bitter compound, rendering them poisonous to humans, even in small amounts. Anyone who has ever picked a pumpkin and hauled it home might be wondering…why on earth would a plant produce fruit weighing more-than-some-dogs that no one can eat?

Well, its turns out there's an answer. And it involves some Jurassic Park level science (but better, because it's real). Read on, fellow nerds…

Read More

Neurotalk S5E6: Tianyi Mao

Today, our guest is Dr. Tianyi Mao, Assistant Scientist and Principal Investigator at the Vollum Institute. We’ll talk about dissecting thalamo-cortical circuits in a systematic way; using sCRACM to understand how circuits are wired; how this approach and these maps could help us understand cortico-striatal-thalamic loops; and, how Dr. Mao’s got to where she is today.

Neurotalk S3E10: Takaki Komiyama

Our guest is in this episode is Takaki Komiyama, a professor at the University of California, San Diego in the Department of Neurosciences and in the Neurobiology Section of the Center for Neural Circuits and Behavior.

Small blast from the past: this episode was recorded in October, 2014, but never broadcast; we wanted to bring this back from our archives and present it to you now, because it’s a great interview!

In this interview, we talk about the anatomy of the sense of smell, baseball (Royals fans, sorry this was 2014...but we're in 2015 now), and neural ensembles in motor cortex during learning. Please enjoy!