How the immune system helps build your brain

How the immune system helps build your brain

Pregnant women who are hospitalized for infections, including the flu, have a slightly higher risk for giving birth to a child with a neurodevelopmental disorder like autism. What's going on? Is the immune system influencing the developing brain? 

Spoilers: yes. And it all starts when immune cells (microglia) are lured into the brain by the siren call of neural progenitor cells. 

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RNA Circles In Your Brain: Noise or a New Class of Genetic Regulators?

RNA Circles In Your Brain: Noise or a New Class of Genetic Regulators?

Molecular biology is still defined by its "central dogma," but we often don’t use the word dogma in science unless we are about to contradict it. Here, Nick Kramer tells us about how circular RNAs, a newly discovered, highly conserved class of RNA molecules, are abundant in the brain and may contribute to its development.

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Neurotalk S5E7: Marc Tessier-Lavigne

Today we'll be speaking with Marc Tessier-Lavigne, Carson Family Professor and at Rockefeller University. We'll be speaking with him about fundamental discoveries of new axon guidance molecules; his career path including many roles in both basic and translational science; and exciting unsolved mysteries in the field of axon guidance.

[Note: Our S5E6 interview with last week's speaker, Tianyi Mao, upcoming!]

Pain in the Brain

Pain in the Brain

"How can the brain think that the brain itself hurts (e.g., during a headache)? Are headaches and migraines (excluding secondary headaches) essentially psychosomatic in nature?"

Before I answer your question, I need to say one important thing: ouch!

That’s right – as I sat down at my keyboard to answer your question, I stubbed my toe quite painfully on my desk. Fortunately, this is a great time to explain how the brain processes pain, which will help answer your question.

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Neurotalk S5E5: Mark George

Today, our guest is Mark George, Professor in the Department of Psychiatry and Behavioral Science at the Medical University of South Carolina (MUSC), where he is director of the Brain Stimulation Laboratory. We’ll be speaking with him about using TMS to probe causality in the human brain, how vagal nerve stimulation could be working to treat depression, and a little bit of entemology /beekeeping. 

Brains that go bump in the night

Brains that go bump in the night

“The witching hour… was a special moment in the middle of the night when every child and every grown-up was in a deep, deep sleep, and all the dark things came out from hiding and had the world all to themselves.”
-Roald Dahl, The BFG

In folklore and literature, the sleeping hours represent a state of heightened vulnerability, a time when the “ghoulies and ghosties, and long-leggedy beasties” roam free and wreak havoc. Today, neuroscientists are unraveling the biological underpinnings of nightmares, night terrors, and other sleep disturbances. 

Recently, I had the chance to sit down to discuss these nighttime phenomena with biologist H. Craig Heller, PhD, a member of the Stanford Neurosciences Institute and an expert in the neurobiology of sleep. 

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